[通过颈动脉血管造影术测定慢性颈内动脉闭塞患者的循环时间：与PET测量的脑血流量和氧代谢的比较]
[Circulation time determined by carotid angiography in patients with chronic internal carotid artery occlusion: comparison with cerebral blood flow and oxygen metabolism measured by PET].
作者信息
Ito H, Inugami A, Shishido F, Okudera T, Ogawa T, Hatazawa J, Fujita H, Shimosegawa E, Kanno I, Fukuda H
机构信息
Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita.
出版信息
Kaku Igaku. 1994 Oct;31(10):1193-9.
The degree of collateral circulation in patients with unilaterally chronic internal carotid artery occlusion was estimated by mean transit time of contrast material in rapid sequence carotid angiography (Angiographic MTT), and compared with cerebral blood flow and oxygen metabolism measured by PET. In normal density region on X-ray CT, a significant negative correlation was observed between Angiographic MTT and cerebral blood flow (CBF). This indicates that cerebral blood flow can be estimated by Angiographic MTT. It has been reported that the ratio of cerebral blood volume (CBV) to CBF (CBV/CBF), i.e., mean transit time determined by PET well agreed with OEF, and is good indicator for brain circulation reserve. In this study, no significant correlation was observed between Angiographic MTT and CBV/CBF. However, a significant positive correlation was observed between Angiographic MTT and oxygen extraction fraction (OEF), and no significant correlation was observed between Angiographic MTT and oxygen consumption rate (CMRO2). These indicates that Angiographic MTT may be indicator for brain circulation reserve.
通过快速序列颈动脉血管造影中造影剂的平均通过时间（血管造影MTT）来估计单侧慢性颈内动脉闭塞患者的侧支循环程度，并与通过PET测量的脑血流量和氧代谢进行比较。在X线CT的正常密度区域，血管造影MTT与脑血流量（CBF）之间观察到显著的负相关。这表明脑血流量可以通过血管造影MTT来估计。据报道，脑血容量（CBV）与CBF的比值（CBV/CBF），即通过PET确定的平均通过时间与氧摄取分数（OEF）非常一致，并且是脑循环储备的良好指标。在本研究中，血管造影MTT与CBV/CBF之间未观察到显著相关性。然而，血管造影MTT与氧摄取分数（OEF）之间观察到显著的正相关，而血管造影MTT与氧消耗率（CMRO2）之间未观察到显著相关性。这些表明血管造影MTT可能是脑循环储备的指标。
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