Ishibashi Y, Ikuma I, Morioka S, Moriyama K
Fourth Department of Internal Medicine, Shimane Medical University.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Aug;32(8):715-20.
We examined the effects of the stopping of oxygen inhalation on pulmonary hemodynamics in 19 patients with stable chronic cor pulmonary with 1 year of Home Oxygen Therapy (HOT). All patients were classified into two groups in which hemodynamic examination was performed under oxygen inhalation (Group A; 10) or under air breathing from 4 hours before examination (Group B; 9). The hemodynamic examination was repeated after 2 hours of stopping oxygen inhalation in Group A, and was repeated 2 hours after restarting oxygen in Group B. The mean pulmonary arterial pressure (mPAP) decreased significantly from 25.2 +/- 7.2 Torr before HOT to 20.4 +/- 3.2 Torr after 1 year of HOT, and then increased to 27.6 +/- 5.6 Torr after stopping oxygen. In contrast, mPAP in Group B did not change: 32.9 +/- 9.4 Torr before HOT, 29.4 +/- 8.2 Torr during stopping of oxygen and 27.6 +/- 5.6 Torr 2 hours after restarting oxygen after 1 year of HOT. These findings suggest that stopping oxygen inhalation in patients with long-term HOT can markedly affect pulmonary hemodynamics as well as the prognosis.
我们研究了19例接受家庭氧疗（HOT）1年的稳定期慢性肺心病患者停止吸氧对肺血流动力学的影响。所有患者分为两组，其中一组（A组，10例）在吸氧状态下进行血流动力学检查，另一组（B组，9例）在检查前4小时呼吸空气状态下进行血流动力学检查。A组在停止吸氧2小时后重复进行血流动力学检查，B组在重新吸氧2小时后重复进行血流动力学检查。平均肺动脉压（mPAP）在家庭氧疗前为25.2±7.2 Torr，家庭氧疗1年后显著降至20.4±3.2 Torr，停止吸氧后又升至27.6±5.6 Torr。相比之下，B组的平均肺动脉压没有变化：家庭氧疗前为32.9±9.4 Torr，停止吸氧期间为29.4±8.2 Torr，家庭氧疗1年后重新吸氧2小时后为27.6±5.6 Torr。这些发现表明，长期接受家庭氧疗的患者停止吸氧会显著影响肺血流动力学以及预后。
