Adam G, Neuerburg J, Spüntrup E, Mühler A, Scherer K, Günther R W
Department of Diagnostic Radiology, University of Technology, Aachen, Germany.
Magn Reson Med. 1994 Nov;32(5):622-8. doi: 10.1002/mrm.1910320511.
The enhancement properties of gadobutrol (40 and 80 mumol/kg body weight, 550 daltons), gadolinium-DTPA-polylysine (20 mumol/kg body weight, 53,000 daltons) and gadolinium-DTPA-cascade-polymer (20 mumol/kg body weight, < 30,000 Daltons) were investigated in abdominal MR imaging using a pig model (n = 24). Signal intensities before and after contrast media application were assessed using a fast single slice FLASH sequence. Measurements were made every 4 s within the first 116 s, every minute between 4 and 10 min and after 15, 20, 30, 40, 50, 60, 90, and 120 min after contrast media injection. Injection of gadobutrol resulted in typical signal intensity curves characterizing it as an extracellular agent similar to gadopentetate dimeglumine. Significant enhancement was found in all tissues except the trunk muscles when the lower dose was administered. Gadolinium-DTPA-polylysine injection resulted also in significant enhancement of the liver, the pancreas, and the renal cortex, but not of the trunk muscle, reflecting its blood pool properties known also from other macromolecular contrast agents. The signal intensity curves obtained after gadolinium-DTPA-cascade-polymer injection were similar to those obtained after polylysine injection, stressing the blood pool character of this new type of blood pool agent.
使用猪模型（n = 24）在腹部磁共振成像中研究了钆布醇（40和80 μmol/kg体重，550道尔顿）、钆喷酸葡胺-聚赖氨酸（20 μmol/kg体重，53,000道尔顿）和钆喷酸葡胺-级联聚合物（20 μmol/kg体重，< 30,000道尔顿）的增强特性。使用快速单层面FLASH序列评估造影剂应用前后的信号强度。在注射造影剂后的前116秒内每4秒进行一次测量，在4至10分钟之间每分钟进行一次测量，并在15、20、30、40、50、60、90和120分钟后进行测量。注射钆布醇产生了典型的信号强度曲线，表明它是一种类似于钆喷酸葡胺的细胞外造影剂。当给予较低剂量时，除躯干肌肉外的所有组织均发现有显著增强。注射钆喷酸葡胺-聚赖氨酸也导致肝脏、胰腺和肾皮质显著增强，但躯干肌肉未增强，这反映了其与其他大分子造影剂相同的血池特性。注射钆喷酸葡胺-级联聚合物后获得的信号强度曲线与注射聚赖氨酸后获得的曲线相似，强调了这种新型血池造影剂的血池特性。
