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Interactions of phenoxyl radical of antitumor drug, etoposide, with reductants in solution and in cell and nuclear homogenates: electron spin resonance and high-performance liquid chromatography.

作者信息

Gantchev T G, van Lier J E, Stoyanovsky D A, Yalowich J C, Kagan V E

机构信息

Department of Nuclear Medicine and Radiobiology, University of Sherbrooke, Québec, Canada.

出版信息

Methods Enzymol. 1994;234:631-42. doi: 10.1016/0076-6879(94)34134-6.

DOI:10.1016/0076-6879(94)34134-6
PMID:7808339
Abstract
摘要

相似文献

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Interactions of phenoxyl radical of antitumor drug, etoposide, with reductants in solution and in cell and nuclear homogenates: electron spin resonance and high-performance liquid chromatography.抗肿瘤药物依托泊苷的苯氧基自由基与溶液、细胞及细胞核匀浆中还原剂的相互作用：电子自旋共振和高效液相色谱法
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Antioxidant paradoxes of phenolic compounds: peroxyl radical scavenger and lipid antioxidant, etoposide (VP-16), inhibits sarcoplasmic reticulum Ca(2+)-ATPase via thiol oxidation by its phenoxyl radical.酚类化合物的抗氧化悖论：过氧自由基清除剂和脂质抗氧化剂依托泊苷（VP - 16）通过其苯氧自由基的硫醇氧化作用抑制肌浆网Ca(2 +)-ATP酶。
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2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation.2,3-二氢-5-羟基-2,2-二戊基-4,6-二叔丁基苯并呋喃：作为一种新型抗脂质过氧化自由基清除抗氧化剂的设计与评价
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Reactions of phenoxyl radicals with NADPH-cytochrome P-450 oxidoreductase and NADPH: reduction of the radicals and inhibition of the enzyme.苯氧基自由基与NADPH-细胞色素P-450氧化还原酶及NADPH的反应：自由基的还原及酶的抑制
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Redox cycling of phenol induces oxidative stress in human epidermal keratinocytes.苯酚的氧化还原循环会在人表皮角质形成细胞中引发氧化应激。
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Reversible thiol-dependent activation of ryanodine-sensitive Ca2+ release channel by etoposide (VP-16) phenoxyl radical.依托泊苷（VP - 16）苯氧基自由基对兰尼碱敏感的Ca2+释放通道的可逆硫醇依赖性激活
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Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.在存活的HL-60细胞中，抗坏血酸/二氢硫辛酸对维生素E同系物2,2,5,7,8-五甲基-6-羟基色烷的髓过氧化物酶催化的苯氧自由基进行循环利用的直接证据。
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引用本文的文献

1
DNA-AP sites generation by etoposide in whole blood cells.依托泊苷在全血细胞中生成 DNA-AP 位点。
BMC Cancer. 2009 Nov 16;9:398. doi: 10.1186/1471-2407-9-398.
2
Combination toxicity of etoposide (VP-16) and photosensitisation with a water-soluble aluminium phthalocyanine in K562 human leukaemic cells.依托泊苷（VP - 16）与水溶性铝酞菁联合作用对K562人白血病细胞的毒性及光致敏作用
Br J Cancer. 1996 Nov;74(10):1570-7. doi: 10.1038/bjc.1996.591.