人α-1-抗胰蛋白酶与曼氏血吸虫尾蚴中成分的复合物形成
Complex formation of human alpha-1-antitrypsin with components in Schistosoma mansoni cercariae.
作者信息
Modha J, Doenhoff M J
机构信息
Department of Biochemistry, University of Glasgow, UK.
出版信息
Parasite Immunol. 1994 Aug;16(8):447-50. doi: 10.1111/j.1365-3024.1994.tb00372.x.
Abstract
Human alpha-1-antitrypsin (alpha 1-AT) was incubated with an extract of Schistosoma mansoni cercariae or porcine pancreatic elastase and analysed by immunoelectrophoresis and Western blotting. The inhibitor was shown to form complexes with components in S. mansoni cercariae in the same way as elastase. The role of alpha 1-AT in S. mansoni infection is discussed.
摘要
将人α1-抗胰蛋白酶（α1-AT）与曼氏血吸虫尾蚴提取物或猪胰弹性蛋白酶一起孵育，然后通过免疫电泳和蛋白质印迹法进行分析。结果表明，该抑制剂与曼氏血吸虫尾蚴中的成分形成复合物的方式与弹性蛋白酶相同。本文讨论了α1-AT在曼氏血吸虫感染中的作用。
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