Mierau G W, Wills E J, Steele P O
Department of Pathology, Children's Hospital, Denver, Colorado 80218.
Pediatr Pathol. 1994 Sep-Oct;14(5):895-904. doi: 10.3109/15513819409037685.
The ultrastructure of lesional cells in biopsy material from 50 cases of Langerhans cell histiocytosis (LCH) was studied for the effects of virus and/or cytokines. Viral "footprints," which actually represent ultrastructural signs of the effects of cytokines on cells, were found in 76% of the cases. These were detected in lesional Langerhans cells, endothelial cells, and lymphocytes and consisted of tubuloreticular structures, cylindrical confronting cisternae, and curvilinear membranous formations. No virus particles or virus-specific cell products were found. These studies suggest that LCH cells are subject to cytokine stimulation but provide no evidence to implicate a virus in the disease process.
对50例朗格汉斯细胞组织细胞增生症（LCH）活检材料中病变细胞的超微结构进行了研究，以探讨病毒和/或细胞因子的作用。在76%的病例中发现了病毒“足迹”，实际上这些代表了细胞因子对细胞作用的超微结构迹象。这些在病变的朗格汉斯细胞、内皮细胞和淋巴细胞中被检测到，由管状网状结构、柱状对置池和曲线状膜性结构组成。未发现病毒颗粒或病毒特异性细胞产物。这些研究表明，LCH细胞受到细胞因子刺激，但没有证据表明病毒参与了疾病过程。
