Wong D K, Heathcote J
Toronto Hospital, Western Division, Ontario, Canada.
Pharmacol Ther. 1994 Aug;63(2):177-86. doi: 10.1016/0163-7258(94)90044-2.
Chronic viral hepatitis, frequently an asymptomatic disease, can persist for decades. Despite the lack of symptoms, prolonged infection can lead to the complications of cirrhosis, liver failure and hepatocellular carcinoma. The goal of therapy is to reduce the risk of developing these complications and to eradicate the infectious pool. Patients with ongoing viral replication appear to be at greatest risk for developing complications. These patients have been targeted for treatment. Numerous randomized studies of interferon treatment of chronic hepatitis B and C have been published in the last 8 years. The experience from these studies and more recent developments will be reviewed.
慢性病毒性肝炎通常是一种无症状的疾病，可持续数十年。尽管没有症状，但长期感染可导致肝硬化、肝衰竭和肝细胞癌等并发症。治疗的目标是降低发生这些并发症的风险并消除感染源。持续病毒复制的患者似乎发生并发症的风险最高。这些患者已成为治疗的目标。在过去8年中，已经发表了许多关于干扰素治疗慢性乙型和丙型肝炎的随机研究。将对这些研究的经验和最新进展进行综述。
