Weems Y S, Vincent D L, Nusser K D, Tanaka Y, Miller-Patrick K, Ledgerwood K S, Weems C W
Department of Animal Sciences, University of Hawaii, Honolulu, 96822.
Prostaglandins. 1994 Sep;48(3):139-56. doi: 10.1016/0090-6980(94)90015-9.
Vehicle or 8 or 16 mg PGF2 alpha/58 kg/body weight (BW) was given intramuscularly to intact, hysterectomized and ovariectomized 90 to 100 day pregnant ewes in three separate experiments. Hysterectomy alone decreased (P < or = 0.05) estradiol-17 beta in jugular venous blood by 80 percent within 16 hours and profiles of estradiol-17 beta did not differ (P > or = 0.05) among vehicle or 8 or 16 mg PGF2 alpha/58 kg/BW-treated ewes. Profiles of estradiol-17 beta differed (P < or = 0.05) in intact pregnant ewes treated with 8 or 16 mg PGF2 alpha/58 kg/BW when compared to controls and in ovariectomized (P < or = 0.10) 90 to 100 day pregnant ewes treated with 16 mg PGF2/58 kg/BW. Estradiol-17 beta decreased (P < or = 0.05) over time in vehicle and 8 mg PGF2 alpha/58 kg/BW-treated intact and in vehicle-treated ovariectomized 90 to 100 day pregnant ewes. Cortisol decreased (P < or = 0.05) over time in hysterectomized, intact, and ovariectomized 90 to 100 days pregnant ewes, but did not differ (P < or = 0.05) among vehicle or 8 or 16 mg PGF2 alpha/58 kg/BW-treated ewes. It is suggested that estradiol-17 beta has a role in regulating ovine placental steroidogenesis.
在三个独立实验中，分别给完整的、子宫切除的和卵巢切除的90至100日龄怀孕母羊肌肉注射载体或8毫克或16毫克前列腺素F2α/58千克体重。单独子宫切除使颈静脉血中雌二醇-17β在16小时内降低了80%（P≤0.05），在接受载体或8毫克或16毫克前列腺素F2α/58千克体重处理的母羊中，雌二醇-17β的变化曲线没有差异（P≥0.05）。与对照组相比，接受8毫克或16毫克前列腺素F2α/58千克体重处理的完整怀孕母羊以及接受16毫克前列腺素F2/58千克体重处理的卵巢切除的90至100日龄怀孕母羊，其雌二醇-17β的变化曲线存在差异（P≤0.05）。在接受载体和8毫克前列腺素F2α/58千克体重处理的完整母羊以及接受载体处理的卵巢切除的90至100日龄怀孕母羊中，雌二醇-17β随时间降低（P≤0.05）。在子宫切除的、完整的和卵巢切除的90至100日龄怀孕母羊中，皮质醇随时间降低（P≤0.05），但在接受载体或8毫克或16毫克前列腺素F2α/58千克体重处理的母羊之间没有差异（P≤0.05）。提示雌二醇-17β在调节绵羊胎盘类固醇生成中起作用。
