Lueder G T, Smith M E
Department of Opthalmology and Visual Science, Washington University School of Medicine, St Louis, MO 63110.
Semin Diagn Pathol. 1994 May;11(2):104-6.
Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.
视网膜母细胞瘤（RB）是儿童期最常见的眼内恶性肿瘤，发病率约为两万分之一活产儿。它起源于多能视网膜祖细胞。RB1基因突变会干扰细胞周期的调控。携带RB1基因生殖系突变的患者有发生第二种非眼部肿瘤的风险。
