未成熟人类T细胞中紫外线诱导的DNA损伤修复缺陷。
Deficient repair of UV-induced DNA damage in immature human T cells.
作者信息
Hartwig M
机构信息
Max Delbrück Center for Molecular Medicine, Berlin.
出版信息
Z Gerontol. 1994 Sep-Oct;27(5):330-3.
PMID:7810201
Abstract
As compared with quiescent lymphocytes, human thymocytes were found in the nucleoid sedimentation assay to be deficient in UV-induced DNA repair. Therefore, the age-related repair deficiency of human lymphocytes can result from the increased proportion of immature T cells occurring with age.
摘要
与静止淋巴细胞相比，在核仁沉降分析中发现人类胸腺细胞在紫外线诱导的DNA修复方面存在缺陷。因此，人类淋巴细胞与年龄相关的修复缺陷可能是由于随着年龄增长未成熟T细胞比例增加所致。
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