Vinogradova O S, Brazhnik E S, Stafekhina V S, Kichigina V F
Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Jul-Oct;44(4-5):751-61.
To evaluate the functional significance of the cholinergic component of the septo-hippocampal input the effects of electrical stimulation of the medial septal area (MS--DB) on the hippocampal neurons were studied in chronic waking rabbits. Initial inhibitory effects 40-140 msec long were observed in 54% of neurons in intact rabbits. Other neurons usually responded by a diffuse excitation. Initial inhibitory effects absolutely dominated (90%) in the animals with the septum basally undercut. Increase of the endogenous acetylcholine level by physostigmine completely or partially blocked the effects of the stimulation in 78% of the hippocampal neurons at the background of increased theta-modulation. Scopolamine restored responsiveness of the neurons to the MS--DB stimulation. These effects were preserved in the animals with the septal undercutting. It is concluded that the general effect of the MS--DB on the hippocampal neurons consists in a non--cholinergic (GABA-ergic) primary suppression (reset) of their activity. The cholinergic component limits the efficacy of both extraseptal (brainstem) and septal inhibitory influences.
为评估隔区-海马输入中胆碱能成分的功能意义，我们在慢性清醒兔中研究了电刺激内侧隔区（MS-DB）对海马神经元的影响。在完整兔中，54%的神经元观察到了持续40-140毫秒的初始抑制作用。其他神经元通常表现为弥漫性兴奋。在基部切断隔区的动物中，初始抑制作用占绝对主导（90%）。在θ调制增强的背景下，毒扁豆碱使内源性乙酰胆碱水平升高，完全或部分阻断了78%海马神经元的刺激效应。东莨菪碱恢复了神经元对MS-DB刺激的反应性。这些效应在切断隔区的动物中得以保留。得出的结论是，MS-DB对海马神经元的总体作用在于对其活动进行非胆碱能（γ-氨基丁酸能）的初级抑制（重置）。胆碱能成分限制了隔区外（脑干）和隔区抑制性影响的效能。
