D'iakonova T L, Samonina G E
Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Jul-Oct;44(4-5):786-95.
Excitatory and oscillogenic action of psychostimulant sydnophen on identified serotoninergic and peptidergic neurons was shown in the Helix brain. Sydnophen induced marked depolarizing shift, increase of the firing activity, activated excitatory synaptic input and generation of endogenous slow depolarizing potentials and burst activity in these neurons. The effect of sydnophen was blocked by naloxone and was imitated by the agonists of opiate receptors morphine and met-enkephalin. Majority of the other studied identified and non-identified neurons in the Helix brain did not react to sydnophen. Selective naloxone-dependent effect of sydnophen and the possible role of endogenous opioid system in the action of psychotropic agents are discussed.
在蜗牛脑内，已证实精神刺激剂西地那芬对已鉴定的5-羟色胺能和肽能神经元具有兴奋和致振荡作用。西地那芬可引起显著的去极化偏移、放电活动增加、激活兴奋性突触输入，并在这些神经元中产生内源性缓慢去极化电位和爆发性活动。西地那芬的作用可被纳洛酮阻断，且可被阿片受体激动剂吗啡和甲硫氨酸脑啡肽模拟。蜗牛脑内大多数其他已研究鉴定和未鉴定的神经元对西地那芬无反应。文中讨论了西地那芬的选择性纳洛酮依赖性作用以及内源性阿片系统在精神药物作用中的可能作用。
