Leclercq J F, Gounaropoulou N, Cauchemez B, Chouty F, Leenhardt A, Beaufils P, Coumel P, Slama R
Service de cardiologie, hôpital Lariboisière, Paris.
Arch Mal Coeur Vaiss. 1994 Jan;87(1):57-63.
The prognostic value of ventricular late potentials (VLP) was studied in 38 survivors of ventricular fibrillation (VF) resuscitated after cardiac arrest. Thirty-seven patients had coronary artery disease, 24 within one month of myocardial infarction, and one patient had valvular heart disease. There were 7 deaths within 2 years, including 5 sudden deaths, the average follow-up in the remaining patients being 46 +/- 30 months. Bad prognostic factors included low left ventricular ejection fraction, anterior myocardial infarction, VF occurring after the first 24 hours of myocardial infarction and the presence of VLP. The 2 year mortality rate was 35% in patients with VLP compared with only 5% when they were absent (p < 0.05). The subgroup with the highest risk of death was that of anterior myocardial infarcts with VLP (45% 2 year mortality). The clinical circumstances surrounding VF were important; patients with clinical and electrical signs of ischaemia at the time of VF tended to have a better prognosis than the others, especially in the absence of VLP: in this subgroup of 12 "ischaemic" VFs without VLP the mortality at 2 years was nil, whereas the other 26 patients had a 27% death rate (0.05 < p < 0.10). Programmed ventricular stimulation was only carried out in 14 cases: it showed that the long-term mortality was very high (60%) in patients with VLP and inducible ventricular tachycardia (VT). Therefore, the implantation of an automatic defibrillator device would seem to be justified in patients resuscitated from VF who have both VLP and inducible VT, but of no value in cases of "ischaemic" VF without VLP.
对38例心脏骤停后复苏成功的心室颤动(VF)幸存者进行了心室晚电位(VLP)的预后价值研究。37例患者患有冠状动脉疾病,其中24例在心肌梗死1个月内发病,1例患者患有瓣膜性心脏病。2年内有7例死亡,其中5例为猝死,其余患者的平均随访时间为46±30个月。不良预后因素包括左心室射血分数低、前壁心肌梗死、心肌梗死后24小时后发生的VF以及VLP的存在。有VLP的患者2年死亡率为35%,而无VLP的患者仅为5%(p<0.05)。死亡风险最高的亚组是伴有VLP的前壁心肌梗死患者(2年死亡率为45%)。VF发生时的临床情况很重要;VF时伴有临床和电活动缺血迹象的患者预后往往比其他患者好,尤其是在没有VLP的情况下:在这个由12例无VLP的“缺血性”VF组成的亚组中,2年死亡率为零,而其他26例患者的死亡率为27%(0.05<p<0.10)。仅对14例患者进行了程控心室刺激:结果显示,有VLP且可诱发室性心动过速(VT)的患者长期死亡率非常高(60%)。因此,对于从VF复苏且同时有VLP和可诱发VT的患者,植入自动除颤器似乎是合理的,但对于无VLP的“缺血性”VF患者则无价值。