Lam S K, To W K
Department of Obstetrics and Gynaecology, University of Hong Kong, Tsan Yuk Hospital.
Asia Oceania J Obstet Gynaecol. 1994 Sep;20(3):231-6. doi: 10.1111/j.1447-0756.1994.tb00462.x.
A retrospective case controlled study was carried out to study the neonatal characteristics, outcome and narcotic withdrawal syndrome in 51 neonates exposed to narcotic antenatally. The birth weight, head circumference and body length were significantly smaller in the study group while the incidence of prematurity (41%) and small-for-gestational age babies was increased (27.5%). Narcotic withdrawal occurred in 83% of narcotic exposed neonates. About half of them had onset of withdrawal symptoms within the first 24 hours. All of these newborns were treated by either phenobarbitone (45%), chlorpromazine (9.5%) or both (40.5%). The average duration of treatment was 15.7 days. There was one neonatal death due to in utero withdrawal and hypoxia, and another post-neonatal death due to sudden infant death. Neonatal jaundice, necrotising enterocolitis, clinical sepsis and congenital syphilis were more common in the drug-addicted group.
开展了一项回顾性病例对照研究，以研究51例产前接触麻醉品的新生儿的新生儿特征、结局及戒断综合征。研究组的出生体重、头围和身长明显较小，同时早产（41%）和小于胎龄儿的发生率增加（27.5%）。83%接触麻醉品的新生儿出现了麻醉品戒断症状。其中约一半在出生后24小时内出现戒断症状。所有这些新生儿均接受苯巴比妥（45%）、氯丙嗪（9.5%）或两者联合治疗（40.5%）。平均治疗时间为15.7天。有1例新生儿因宫内戒断和缺氧死亡，另1例新生儿期后死亡，死因是婴儿猝死综合征。吸毒成瘾组新生儿黄疸、坏死性小肠结肠炎、临床败血症和先天性梅毒更为常见。
