Pickering T G, Levenstein M, Walmsley P
Hypertension Center, New York Hospital-Cornell Medical Center, NY 10021.
Am J Hypertens. 1994 Sep;7(9 Pt 1):848-52. doi: 10.1093/ajh/7.9.848.
In this study the effects of a single daily dose of doxazosin (an alpha-adrenergic blocker) given at night were evaluated in 112 patients with mild hypertension. Patients were studied first on no medication, and a second time after being treated for up to 16 weeks with doxazosin. Blood pressure (BP) was measured by noninvasive ambulatory monitoring at the beginning and end of the study. Before treatment, the white coat effect (clinic-ambulatory BP) was greater in women than in men (significant for systolic pressure but not diastolic), and greater in elderly (aged over 65 years) than in younger patients (significant for both systolic and diastolic pressure). Clinic and ambulatory BP were reduced to a similar extent in men and women by doxazosin, but in the elderly the fall in clinic BP was associated with a much smaller fall of ambulatory BP. In patients with white coat hypertension (elevated clinic but normal ambulatory BP) doxazosin lowered clinic but not ambulatory BP, while in those with sustained hypertension it lowered both.
在本研究中，对112例轻度高血压患者评估了夜间每日单次服用多沙唑嗪（一种α-肾上腺素能阻滞剂）的效果。首先在未用药的情况下对患者进行研究，然后在使用多沙唑嗪治疗长达16周后再次进行研究。在研究开始和结束时通过无创动态监测测量血压（BP）。治疗前，女性的白大衣效应（诊室血压与动态血压）大于男性（收缩压有显著差异，舒张压无显著差异），且老年人（年龄超过65岁）大于年轻患者（收缩压和舒张压均有显著差异）。多沙唑嗪使男性和女性的诊室血压和动态血压降低程度相似，但在老年人中，诊室血压的下降与动态血压的下降幅度小得多相关。在白大衣高血压患者（诊室血压升高但动态血压正常）中，多沙唑嗪降低了诊室血压但未降低动态血压，而在持续性高血压患者中，它降低了两者。
