Vollman J H, Smith W L, Ballard E T, Light I J
J Pediatr. 1976 Aug;89(2):199-203. doi: 10.1016/s0022-3476(76)80447-7.
Thirty-one neonates with early onset of serious group B streptococcal infections were observed in a four-year period. The mortality was 52%. Premature infants with clinical signs of respiratory distress syndrome were at highest risk of death; clinical signs of RDS were typical until apnea, shock, respiratory failure, and worsening of the radiographic pattern unexpectedly intervened. Pathologic material from infants with radiographic evidence either of RDS or of pneumonia showed both typical hyaline membrane disease and pneumonia in most instances. Factors which may be helpful in recognizing premature infants at risk for GBS disease in the much larger group of premature infants with uncomplicated RDS include: history of artificial, premature, or prolonged rupture of membranes; localized pulmonary infiltrates on chest roentgenogram; low absolute neutrophil count; and an unusually rapid progression of RDS.
在四年时间里观察了31例早发型严重B族链球菌感染的新生儿。死亡率为52%。有呼吸窘迫综合征临床体征的早产儿死亡风险最高；直到呼吸暂停、休克、呼吸衰竭以及X线影像表现意外恶化之前，呼吸窘迫综合征的临床体征都是典型的。有X线证据显示患有呼吸窘迫综合征或肺炎的婴儿的病理材料在大多数情况下都显示出典型的透明膜病和肺炎。在大量患有无并发症呼吸窘迫综合征的早产儿中，可能有助于识别有感染B族链球菌疾病风险的早产儿的因素包括：人工、早产或胎膜早破时间延长史；胸部X线片上的局限性肺部浸润；绝对中性粒细胞计数低；以及呼吸窘迫综合征异常快速的进展。
