Matsumori Y, Katakami N, Ito M, Taniguchi T, Iwata N, Takaishi T, Chihara K, Matsui T
Department of Medicine, Kobe University School of Medicine, Japan.
Cancer Res. 1995 Jan 15;55(2):276-9.
The brain-gut hormones, gastrin and cholecystokinin, have a trophic effect on the gastrointestinal mucosa in vivo and promote the growth of several neoplastic cell lines. In this study, cholecystokinin-B/gastrin receptor has been demonstrated to provide a novel molecular marker for the diagnosis of small cell lung cancer by using biopsy specimens. Physiological expression of the receptor mRNA is detectable in particular areas of the human brain, stomach, and pancreas but not in the lung. The receptor mRNA was detected selectively in all small cell lung cancer (10 cases) with a RT-PCR assay. By contrast, it was detectable in only 1 of 13 squamous cell carcinomas or 21 adenocarcinomas of the lung. Thus, the cholecystokinin-B/gastrin receptor could be an attractive therapeutic target for small cell lung cancer.
脑肠肽胃泌素和胆囊收缩素在体内对胃肠道黏膜具有营养作用，并能促进多种肿瘤细胞系的生长。在本研究中，通过活检标本证实胆囊收缩素B/胃泌素受体可为小细胞肺癌的诊断提供一种新的分子标志物。该受体mRNA的生理表达在人脑、胃和胰腺的特定区域可检测到，但在肺中未检测到。采用逆转录聚合酶链反应（RT-PCR）法在所有10例小细胞肺癌中均选择性检测到该受体mRNA。相比之下，在13例肺鳞状细胞癌或21例肺腺癌中仅1例可检测到该受体mRNA。因此，胆囊收缩素B/胃泌素受体可能是小细胞肺癌一个有吸引力的治疗靶点。
