Gupta S C, Agarwal J, Singh P A, Mehdiratta N K, Keswani N K
Department of Pathology, M.L.N. Medical College, Allahabad.
Indian J Pathol Microbiol. 1994 Jul;37(3):319-26.
A sequential study of serum immunoglobulins, circulating immune-complexes (CIC) and blocking effect of patients' sera on normal T lymphocytes was conducted in 15 patients with benign ovarian tumour, 32 with carcinoma ovary and 20 agematched healthy women. In patients with benign ovarian tumour there was a significant increase in IgG and IgM, while IgA was not altered. In carcinoma, there was no significant change in IgG and IgM but IgA was found to be increased significantly as compared to benign ovarian tumour. Post-operatively, IgM showed a significant increase on the 10th day, probably due to the effect of surgery. There was no significant difference in CIC levels and percentage T cell depression between patients with benign ovarian tumours and healthy controls. In carcinoma ovary both these parameters were increased significantly as compared to benign ovarian tumours. After tumour ablation, they were decreased significantly, until there was recurrence. The alterations in these parameters was not related to any specific histologic type of neoplasm. The study of serum immunoglobulins indicates tumour load, while the estimation of CIC and blocking effect of cancer sera on normal lymphocytes is of a definite diagnostic and prognostic significance.
对15例卵巢良性肿瘤患者、32例卵巢癌患者及20例年龄匹配的健康女性进行了血清免疫球蛋白、循环免疫复合物（CIC）以及患者血清对正常T淋巴细胞阻断作用的序贯研究。卵巢良性肿瘤患者的IgG和IgM显著升高，而IgA无变化。在卵巢癌患者中，IgG和IgM无显著变化，但与卵巢良性肿瘤相比，IgA显著升高。术后第10天，IgM显著升高，可能是手术的影响。卵巢良性肿瘤患者与健康对照者的CIC水平及T细胞抑制百分比无显著差异。与卵巢良性肿瘤相比，卵巢癌患者的这两个参数均显著升高。肿瘤切除后，它们显著下降，直至复发。这些参数的改变与任何特定的肿瘤组织学类型无关。血清免疫球蛋白的研究表明肿瘤负荷，而CIC的测定以及癌血清对正常淋巴细胞的阻断作用具有明确的诊断和预后意义。
