Koley K M, Lal J
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly.
Indian J Physiol Pharmacol. 1994 Jul;38(3):223-5.
Neem leaf alcoholic extract (NLE) was investigated for its effects on the ECG and blood pressure of rat. Intravenous administration of NLE (100, 300 and 1000 mg/kg) resulted in initial bradycardia followed by cardiac arrhythmia in rats. NLE produced a significant and dose-related fall in blood pressure which was immediate, sharp and persistent. Pre-treatment with either atropine or mepyramine failed to prevent the hypotensive effect of NLE.
研究了印楝叶乙醇提取物（NLE）对大鼠心电图和血压的影响。静脉注射NLE（100、300和1000mg/kg）导致大鼠最初出现心动过缓，随后出现心律失常。NLE使血压显著下降，且呈剂量相关，这种下降是即时、急剧且持续的。用阿托品或美吡拉敏预处理均未能预防NLE的降压作用。
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