抗精神病药物在双相抑郁中起作用吗？
Is there a role for neuroleptics in bipolar depression?
作者信息
Hendrick V, Altshuler L L, Szuba M P
机构信息
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine.
出版信息
J Clin Psychiatry. 1994 Dec;55(12):533-5.
BACKGROUND
Lithium, carbamazepine, and valproic acid reduce relapse rates in most bipolar patients. However, some patients with bipolar illness fail to obtain antidepressant benefits from these medications, despite appropriate dosages of and duration on therapy with these drugs.
METHOD
Three bipolar patients were followed in an open fashion on thymoleptic and neuroleptic medications. With discontinuation of neuroleptics, each patient relapsed into depression and was then restarted on neuroleptic treatment.
RESULTS
These three patients responded rapidly to readministration of neuroleptics to their pharmacologic regimen.
CONCLUSION
Some bipolar patients experience depressive relapse following neuroleptic discontinuation. With reinstitution of the neuroleptic, they show rapid improvement in mood.
背景
锂盐、卡马西平和丙戊酸可降低大多数双相情感障碍患者的复发率。然而，一些双相情感障碍患者尽管接受了这些药物的适当剂量和疗程治疗，仍未能从这些药物中获得抗抑郁益处。
方法
对三名双相情感障碍患者以开放方式使用心境稳定剂和抗精神病药物进行随访。停用抗精神病药物后，每位患者均复发为抑郁状态，随后重新开始抗精神病药物治疗。
结果
这三名患者在重新将抗精神病药物纳入其药物治疗方案后迅速产生反应。
结论
一些双相情感障碍患者在停用抗精神病药物后会出现抑郁复发。重新使用抗精神病药物后，他们的情绪迅速改善。
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