May M, Wette R, Hardin W B, Sullivan J
Laryngoscope. 1976 Aug;86(8):1111-22. doi: 10.1288/00005537-197608000-00003.
A prospective, controlled, double-blind study was designed to evaluate the effect of steroid treatment on the natural history of Bell's palsy. Fifty-one patients were included in the study between 1972 and 1974. The patients were evaluated and started on treatment within two days of onset of Bell's palsy and followed for six months. Treatment was given in randomized double-blind fashion and consisted of either vitamins or a total of 410 mg of prednisone plus vitamins in descending doses over 10 days. The recovery of facial motor function was determined by three physicians who had no knowledge of the treatment received by the patients. They examined photographs of the patients taken six months after onset of paralysis in eight positions of facial function and categorized them as to complete fair, or poor recovery of facial function. These results of this evaluation were submitted to the biostatistician who broke the treatment code. The results of this study demonstrate no statistically significant beneficial effect of steroid therapy upon recovery from Bell's palsy. Factors considered included the patients' age, sex, the presence of pain, ageusia, hyperacusis, diabetes, hypertension, the progression and degree of palsy, the results of nerve excitability and salivary flow tests, and the time at which recovery was first noted or became complete. Bell's palsy remains without a proven efficacious treatment.
一项前瞻性、对照、双盲研究旨在评估类固醇治疗对贝尔面瘫自然病程的影响。1972年至1974年间，51名患者纳入该研究。患者在贝尔面瘫发病两天内接受评估并开始治疗，随访六个月。治疗采用随机双盲方式，包括服用维生素或总共410毫克泼尼松加维生素，泼尼松剂量在10天内递减。由三名对患者所接受治疗不知情的医生确定面部运动功能的恢复情况。他们检查了患者在面瘫发作六个月后八个面部功能位置的照片，并将面部功能恢复情况分为完全恢复、尚可恢复或恢复不佳。该评估结果提交给打破治疗代码的生物统计学家。这项研究结果表明，类固醇疗法对贝尔面瘫恢复没有统计学上的显著有益效果。考虑的因素包括患者的年龄、性别、是否存在疼痛、味觉丧失、听觉过敏、糖尿病、高血压、麻痹的进展和程度、神经兴奋性和唾液流量测试结果，以及首次注意到恢复或恢复完成时间。贝尔面瘫仍然没有经过证实的有效治疗方法。
