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儿童肾脏疾病尿蛋白成分的研究,II——体位性蛋白尿患儿与肾小球肾炎缓解期患儿的比较

[Studies on urinary protein components in renal disease in children, II--Comparison between children with orthostatic albuminuria and children with remission of glomerulonephritis].

作者信息

Ohshima T

机构信息

Department of Pediatrics, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Nihon Jinzo Gakkai Shi. 1994 Oct;36(10):1137-44.

PMID:7815746
Abstract

The urinary protein components of 14 children with orthostatic albuminuria (group OA) and also that of 9 children with remission of IgA nephropathy or Henoch-Schönlein purpura nephritis (group GN) after forced lordosis were analyzed. The results were as follows; (1) Urinary total protein excretions after forced lordosis were greater than 30mg/dl in 50% of 26 children with remission of glomerulonephritis, therefore a high percentage of children with remission of glomerulonephritis were complicated with orthostatic albuminuria. (2) Urinary total protein excretions after forced lordosis were 150 +/- 91mg/dl in the group of OA and 149 +/- 88mg/dl in GN (p > 0.05). (3) In the urinary protein components, the percentage of urinary albumin and alpha 1-antichymotrypsin excretions were significantly higher in the OA group than the GN group (p < 0.01, p < 0.001 respectively), while the percentage of urinary transferrin, IgA and IgG excretions were significantly higher in the GN group than the OA group (p < 0.01, p < 0.001 and p < 0.05 respectively). (4) The ratio of urinary IgG/IgA and serum IgG/IgA was significantly lower in the GN group than the OA group (p < 0.05), suggesting that serum IgA tended to be excreted in urine in the GN group.

摘要

对14例直立性蛋白尿患儿(OA组)以及9例在强迫脊柱前凸后IgA肾病或过敏性紫癜性肾炎缓解的患儿(GN组)的尿蛋白成分进行了分析。结果如下:(1)26例肾小球肾炎缓解患儿中,50%在强迫脊柱前凸后的尿总蛋白排泄量大于30mg/dl,因此,高比例的肾小球肾炎缓解患儿合并直立性蛋白尿。(2)OA组强迫脊柱前凸后的尿总蛋白排泄量为150±91mg/dl,GN组为149±88mg/dl(p>0.05)。(3)在尿蛋白成分中,OA组尿白蛋白和α1-抗糜蛋白酶排泄的百分比显著高于GN组(分别为p<0.01,p<0.001),而GN组尿转铁蛋白、IgA和IgG排泄的百分比显著高于OA组(分别为p<0.01,p<0.001和p<0.05)。(4)GN组尿IgG/IgA和血清IgG/IgA的比值显著低于OA组(p<0.05),提示GN组血清IgA有向尿中排泄的倾向。

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