[New formation of the skeletal muscles and skeletal muscle and myocardial-like structures in rabbits in experiments with diffusion chambers].

The rabbit skeletal and cardiac muscles treated by 1% water solution of Trypan Blue for 48 hrs are necrotized and, having been transplanted under the skin in the diffusion chambers impermeable for cells, do not develop. When transplanting such necrotized muscles under the skin or in the abdominal cavity in the diffusion chambers permeable for cells (with pores of 1.5 mu in diameter), cells penetrate through the chamber wall and develop, under the influence of the products of decomposition of phagocytized transplant, into myoblasts, muscular tubes and differentiated cross-striated muscle fibers; undifferentiated muscle fibers of the skeletal type arise outside the chamber. The necrotized cardiac muscle did not induce the formation of muscle fibers after the transplantation under the skin or in the omentum. If they were transplanted together with the diffusion chambers containing the necrotized skeletal muscles, myocardium-like structures arose outside the chamber. The formation de novo of skeletal muscles and skeletal muscle- and myocardium-like structures under the influence of decomposition products released from the necrotized skeletal and cardiac muscles proceeds by means of induction; some pluripotent cells of the recipient, possibly polyblasts, are the source of de novo formation.