Buijsen J G, van Acker B A, Koomen G C, Koopman M G, Arisz L
Department of Internal Medicine, Academic Medical Center, Amsterdam, The Netherlands.
Nephrol Dial Transplant. 1994;9(9):1330-3.
Within 6 months of a kidney transplantation the graft can be regarded as an organ deprived of its innervation. We analysed whether the transplanted kidney has a diurnal rhythm of its glomerular filtration rate (GFR) similar to the GFR rhythm that has been demonstrated in normal individuals and in patients with nephrotic syndrome. GFR was measured by inulin clearances every 3 h during 1 day of bed-rest and identical food and fluid intake per 3 h in seven patients, 4-7 months after a successful kidney transplantation, and in 10 healthy volunteers. Similar to these healthy subjects, a normal circadian rhythm of GFR was detected in all but one patient with a maximum of 57 (range 45-82) ml/min in daytime, a minimum of 47 (range 36-70) ml/min during the night and a relative amplitude of 21 (range 10-41)%. The circadian rhythm of GFR was absent in the patient with the lowest value of GFR (39 ml/min). In conclusion, GFR has a circadian rhythm in patients studied within 6 months of a kidney transplantation, despite the absence of renal innervation.
在肾移植后的6个月内，移植肾可被视为一个失去神经支配的器官。我们分析了移植肾的肾小球滤过率（GFR）是否具有昼夜节律，这种节律类似于在正常个体和肾病综合征患者中所证实的GFR节律。在7例成功肾移植后4 - 7个月的患者以及10名健康志愿者中，在卧床休息1天期间，每3小时通过菊粉清除率测量GFR，并且每3小时给予相同的食物和液体摄入量。与这些健康受试者相似，除了一名患者外，所有患者均检测到正常的GFR昼夜节律，白天最高为57（范围45 - 82）ml/min，夜间最低为47（范围36 - 70）ml/min，相对振幅为21（范围10 - 41）%。GFR最低值（39 ml/min）的患者不存在GFR昼夜节律。总之，尽管缺乏肾神经支配，但在肾移植后6个月内研究的患者中，GFR具有昼夜节律。
