Falk S J, Ramsay J R, Ward R, Miles K, Dixon A K, Bleehen N M
University Department of Clinical Oncology and Radiotherapeutics, Addenbrooke's Hospital, Cambridge, UK.
Radiother Oncol. 1994 Sep;32(3):210-7. doi: 10.1016/0167-8140(94)90020-5.
The effects of escalating doses of BW12C on normal tissue and tumour blood flow and pO2 in patients were studied. BW12C infusion resulted in a significant reduction in median subcutaneous tissue pO2, and an increase in the proportion of hypoxic values (< or = 2.5 mmHg). In 8 of 9 patients with accessible tumours there was a significant reduction in pO2 during BW12C infusion, but no effect on the proportion of hypoxic values. A rapid decline in normal tissue pO2 in the first 10 min was associated with an increase in skin red cell flux and a reduction of normal subcutaneous tissue, muscle, and tumour red cell flux of 30-50%, that was maintained throughout a subsequent 1-h infusion of BW12C. Tumour perfusion, as measured by dynamic computed tomography, was slightly reduced in five out of six patients studied during BW12C infusion. BW12C reduces both subcutaneous tissue and tumour pO2 in patients. Both haemoglobin modification and reduction in blood flow are probably associated with this effect.
研究了递增剂量的BW12C对患者正常组织、肿瘤血流及血氧分压（pO2）的影响。输注BW12C导致皮下组织中位pO2显著降低，且低氧值（≤2.5 mmHg）比例增加。在9例可触及肿瘤的患者中，8例在输注BW12C期间pO2显著降低，但对低氧值比例无影响。最初10分钟内正常组织pO2迅速下降，同时皮肤红细胞通量增加，正常皮下组织、肌肉和肿瘤红细胞通量降低30% - 50%，在随后1小时的BW12C输注过程中这一情况持续存在。在接受研究的6例患者中，5例在BW12C输注期间通过动态计算机断层扫描测量的肿瘤灌注略有降低。BW12C可降低患者皮下组织和肿瘤的pO2。血红蛋白修饰和血流减少可能均与这一效应有关。
