Vilafranca M, Domingo M, Ferrer L
Unidad de Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad Autónoma de Barcelona, Spain.
Res Vet Sci. 1994 Sep;57(2):248-50. doi: 10.1016/0034-5288(94)90066-3.
The expression of the intermediate filament vimentin was examined immunocytochemically in 17 cases of histologically confirmed primary canine nephropathy, and compared with its expression in normal canine kidney. In normal renal tissue, the expression of vimentin was restricted to glomerular elements, but in all cases of chronic interstitial nephritis it extended to the cortical tubular epithelia, and was correlated with the degree of tubulo-interstitial damage. Three of four cases of renal cell carcinoma had vimentin reactivity in neoplastic cells. In only one case of familial renal disease was vimentin expressed in scattered epithelial cells of the cortical tubules.
采用免疫细胞化学方法检测了17例经组织学确诊的原发性犬肾病中中间丝波形蛋白的表达情况，并将其与正常犬肾中的表达进行了比较。在正常肾组织中，波形蛋白的表达仅限于肾小球成分，但在所有慢性间质性肾炎病例中，其表达扩展至皮质肾小管上皮，且与肾小管间质损伤程度相关。四例肾细胞癌中有三例肿瘤细胞呈波形蛋白反应性。仅在一例家族性肾病中，波形蛋白在皮质肾小管的散在上皮细胞中表达。
