Strnad V, Sauer R, Tacev T
Klinik und Poliklinik für Strahlentherapie, Universität Erlangen-Nürnberg.
Strahlenther Onkol. 1994 Dec;170(12):700-3.
We tested, whether inhalation a of gas mixture containing 8.0 to 8.5% O2 reduces the radiosensitivity of healthy tissue in order to deliver higher tumor doses without increasing the side effects of radiation therapy.
In this study 165 patients were treated in the Clinic of Radiation Oncology Erlangen (Germany) and in the Institute of Oncology in Brno (Czech Republic) in the period of January 1986 to December 1993. In 108 patients external irradiation was applied using acute hypoxia (group A--hypoxyradiotherapy). This group was compared with a conventional therapy group of 57 patients (group B). The majority of the patients had advanced tumor of cervix uteri or of rectum. In 89% of patients of group A and in 61% patients of group B external irradiation was applied with portals > 20 x 15 cm2 (p < 0.01). The mean dose in the group A was increased about 30% compared to the mean dose of group B (55.2 Gy vs. 43.6 Gy; p < 0.01).
Despite this increase in dose and large-field irradiation in most cases in group A no differences were found between group A and B concerning acute or late effects of radiation therapy.
The aerogen acute hypoxia (hypoxyradiotherapy) is so far not only the simplest, but also one of the most effective selective radioprotective methods.
我们测试了吸入含8.0%至8.5%氧气的混合气体是否能降低健康组织的放射敏感性，以便在不增加放射治疗副作用的情况下给予更高的肿瘤剂量。
本研究纳入了1986年1月至1993年12月期间在德国埃尔朗根放射肿瘤诊所和捷克布尔诺肿瘤研究所接受治疗的165例患者。108例患者采用急性低氧进行外照射（A组——低氧放疗）。该组与57例患者的传统治疗组（B组）进行比较。大多数患者患有晚期子宫颈癌或直肠癌。A组89%的患者和B组61%的患者采用面积大于20×15 cm²的射野进行外照射（p<0.01）。A组的平均剂量比B组增加了约30%（55.2 Gy对43.6 Gy；p<0.01）。
尽管A组在大多数情况下剂量增加且采用大野照射，但在放射治疗的急性或晚期效应方面，A组和B组之间未发现差异。
目前，气体诱导急性低氧（低氧放疗）不仅是最简单的，也是最有效的选择性放射防护方法之一。
