Trinick J
Division of Molecular and Cellular Biology, Bristol University School of Veterinary Science, Langford, UK.
Trends Biochem Sci. 1994 Oct;19(10):405-9. doi: 10.1016/0968-0004(94)90088-4.
Titin and nebulin are giant muscle proteins, both of which are approximately 1 micron long and are composed of many repeating domains. Titin domains resemble type III fibronectin and C-2 immunoglobulins. Both proteins are likely to be involved in specifying and stabilizing the highly ordered structure of muscle, probably by acting as 'protein rulers' to regulate the assembly of myosin and actin filaments precisely.
肌联蛋白和伴肌动蛋白是巨大的肌肉蛋白，二者长度均约为1微米，且都由许多重复结构域组成。肌联蛋白结构域类似于III型纤连蛋白和C2免疫球蛋白。这两种蛋白质可能都参与了确定和稳定肌肉的高度有序结构，可能是通过充当“蛋白质标尺”来精确调节肌球蛋白和肌动蛋白丝的组装。
