Kowalska A
Swietokrzyskie Centrum Onkologii.
Wiad Lek. 1994 May;47(9-10):368-70.
Together with increasing therapeutic effectiveness neoplastic diseases, the interest in late consequences of adverse effects of chemotherapy is increasing. Such problems include disturbances of gonad function. Treatment of neoplastic diseases leads frequently to infertility and hormonal disturbances resulting from damages to the gonads. Many attempts have been undertaken at protection of the gonads against unfavourable action of drugs. They are based mainly on the "interruption" of the hypothalamo-hypophyseo-gonadal axis in order to make the gonads quiescent. Other direction includes the influence on the metabolism of oncological drugs aimed at inhibition of the development of gonadotoxic derivatives. Another method includes appropriate choice of cytostatics: antimetabolites exert weaker unfavourable action on the gonads than alkylating drugs. The problem of gonad protection remains open. Searching is necessary for drugs without gonadotoxic action and effective methods of protection.
随着肿瘤疾病治疗效果的提高，人们对化疗不良反应的远期后果越来越关注。这类问题包括性腺功能紊乱。肿瘤疾病的治疗常常导致不育以及性腺受损引起的激素紊乱。人们已进行了许多保护性腺免受药物不良作用影响的尝试。这些尝试主要基于下丘脑 - 垂体 - 性腺轴的“中断”，以使性腺静止。另一个方向是影响肿瘤药物的代谢，旨在抑制性腺毒性衍生物的产生。另一种方法包括适当选择细胞毒性药物：抗代谢药物对性腺的不良作用比烷基化药物弱。性腺保护问题仍然悬而未决。有必要寻找无性腺毒性作用的药物和有效的保护方法。
