Montañés Medina P, Torrubia Romero F J, González Baena A C, Martínez Rodríguez J, Cruz Navarro N
Servicio Universitario Virgen del Rocío, Sevilla.
Actas Urol Esp. 1994 Oct;18(9):865-70.
The higher risk of developing malignant tumours in transplanted patients is a fact widely acknowledged over the last decade. This paper includes an analysis of our series and a review of the literature. Cancers developed by the transplanted patient or "de novo" cancers and, within this group skin and lip cancer (58%), are by far the most frequent ones. Their biological behaviour is, in general, more aggressive than similar ones in non-transplanted population. Also, different incidence rates and behaviour have been established depending on the immunosuppressive regime given to the patient. Most common pre-existing carcinoma was renal cancer (one third of cases). When these patients had been adequately treated before the transplant, the minimum disease-free interval that has to elapse to be included in a waiting list will depend on the type of tumour. Transferred tumours are the least frequent but more worrying ones due to both their clinical and legal implications. In view of the existing evidence, it is of particular relevance to insure the primitive nature of any CNS tumour as well as the absence of tumoral disease in young females who die of brain haemorrhage.
在过去十年中,移植患者发生恶性肿瘤的较高风险是一个被广泛认可的事实。本文包括对我们系列病例的分析以及文献综述。移植患者发生的癌症或“新发”癌症,其中皮肤和唇癌(58%)是迄今为止最常见的。总体而言,它们的生物学行为比非移植人群中的类似癌症更具侵袭性。此外,根据给予患者的免疫抑制方案,已确定了不同的发病率和行为。最常见的原有癌症是肾癌(占病例的三分之一)。当这些患者在移植前得到充分治疗时,被列入等候名单必须经过的最短无病间隔时间将取决于肿瘤类型。转移性肿瘤是最不常见但更令人担忧的,因为它们具有临床和法律方面的影响。鉴于现有证据,确保任何中枢神经系统肿瘤的原始性质以及死于脑出血的年轻女性不存在肿瘤疾病尤为重要。