Geleziunas R, Bour S, Wainberg M A
Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Adv Virus Res. 1994;44:203-66. doi: 10.1016/s0065-3527(08)60330-9.
This chapter discusses human immunodeficiency virus type 1 (HIV-1) associated with CD4 downmodulation. It also discusses the structure and function of CD4 and p56 and factors involved in hiv-1-associated cd4 downmodulation. There are, at present, at least three HIV-1 gene products known to be involved in cell surface CD4 downmodulation. These are Nef, Vpu, and gp160. Whereas Nef is expressed during the early phase of HIV-1 gene expression, both Vpu and gp160, which appear to act coordinately, are expressed during the late phase. This functional convergence of HIV-1 proteins on cell surface CD4 downmodulation, whether specific or nonspecific in activity, suggests that this event is of critical importance in the life cycle of HIV-1. Further elucidation of the mechanisms that underlie CD4 cell surface downmodulation may lead to the development of novel strategies aimed at preventing such events, and potentially to the development of new therapeutic approaches.
本章讨论与CD4下调相关的1型人类免疫缺陷病毒（HIV-1）。它还讨论了CD4和p56的结构与功能以及参与HIV-1相关CD4下调的因素。目前，已知至少有三种HIV-1基因产物参与细胞表面CD4的下调。它们是Nef、Vpu和gp160。Nef在HIV-1基因表达的早期阶段表达，而Vpu和gp160似乎协同作用，在晚期阶段表达。HIV-1蛋白在细胞表面CD4下调方面的这种功能趋同，无论其活性是特异性的还是非特异性的，都表明这一事件在HIV-1的生命周期中至关重要。进一步阐明CD4细胞表面下调的潜在机制可能会导致开发旨在预防此类事件的新策略，并有可能开发新的治疗方法。
