Skender L, Karacic V, Bosner B, Prpić-Majić D
Institute for Medical Research and Occupational Health University of Zagreb, Croatia.
Arch Environ Health. 1994 Nov-Dec;49(6):445-51. doi: 10.1080/00039896.1994.9954999.
Exposure of the general population to trichloroethylene and tetrachloroethylene under normal environmental conditions, achieved with biological monitoring, was assessed, and the possible influence of these compounds via drinking water on the body burden was revealed. A total of 79 subjects with no known solvent exposure was selected, by stratified sampling, from the residents of the city of Zagreb. Trichloroethylene and tetrachloroethylene were determined in blood, and trichloroethanol and trichloroacetic acid were determined in plasma and urine. Drinking water samples were also analyzed for trichloroethylene and tetrachloroethylene. Concentrations of trichloroethylene and tetrachloroethylene in blood, trichloroacetic acid in plasma, trichloroacetic acid in urine, trichloroethylene in drinking water, and tetrachloroethylene in drinking water were as follows: < 0.015 to 0.090 micrograms/l, < 0.010 to 0.239 micrograms/l, 8.6 to 148.1 micrograms/l, 1.67 to 102.3 micrograms/24 h, < 0.05 to 22.93 micrograms/l, and 0.21 to 7.80 micrograms/l, respectively. The variation in all results presented is probably a reflection of different environmental contamination with trichloroethylene and tetrachloroethylene in the different city areas. Correlation analyses revealed significant relationships between trichloroethylene and tetrachloroethylene in blood (r = .402, p = .0004); trichloroacetic acid in urine and in plasma (r = .522, p = .0000); and trichloroethylene and tetrachloroethylene in drinking water (r = .800, p = .0000). A division of all parameters into a subgroup (n = 58), taking drinking water concentrations of trichloroethylene above 3 micrograms/l as a basis, demonstrated the same significant relationships as mentioned above.(ABSTRACT TRUNCATED AT 250 WORDS)
通过生物监测评估了正常环境条件下普通人群对三氯乙烯和四氯乙烯的暴露情况，并揭示了这些化合物通过饮用水对体内负荷的可能影响。通过分层抽样从萨格勒布市居民中选取了79名无已知溶剂暴露史的受试者。测定了血液中的三氯乙烯和四氯乙烯，以及血浆和尿液中的三氯乙醇和三氯乙酸。还对饮用水样本进行了三氯乙烯和四氯乙烯分析。血液中三氯乙烯和四氯乙烯的浓度、血浆中三氯乙酸的浓度、尿液中三氯乙酸的浓度、饮用水中三氯乙烯的浓度以及饮用水中四氯乙烯的浓度分别如下：<0.015至0.090微克/升、<0.010至0.239微克/升、8.6至148.1微克/升、1.67至102.3微克/24小时、<0.05至22.93微克/升和0.21至7.80微克/升。所有呈现结果的差异可能反映了不同城市区域三氯乙烯和四氯乙烯的环境污染程度不同。相关性分析显示血液中三氯乙烯和四氯乙烯之间存在显著关系（r = 0.402，p = 0.0004）；尿液和血浆中三氯乙酸之间存在显著关系（r = 0.522，p = 0.0000）；饮用水中三氯乙烯和四氯乙烯之间存在显著关系（r = 0.800，p = 0.0000）。以饮用水中三氯乙烯浓度高于3微克/升为基础，将所有参数分为一个亚组（n = 58），结果显示了上述相同的显著关系。（摘要截短至250字）
