从人类5号染色体脊髓性肌萎缩区域鉴定多个转录序列。
Identification of multiple transcribed sequences from the spinal muscular atrophy region of human chromosome 5.
作者信息
Pizzuti A, Colosimo A, Ratti A, Capon F, Gennarelli M, Silani V, Ghezzi C, Lo Cicero S, Calabrese G, Palka G
机构信息
Istituto di Neurologia, Università di Milano, Italy.
出版信息
Biochem Biophys Res Commun. 1995 Jan 5;206(1):294-301. doi: 10.1006/bbrc.1995.1041.
We report the isolation and characterization of novel expressed sequences from the spinal muscular atrophy (SMA) region on human chromosome 5q13. Based on the sequence homology studies these cDNAs were grouped in four classes, one of which shows extensive homologies with the beta-glucuronidase (BG) gene, differing in exon arrangement. The other cDNAs do not show any strong homology with known DNA sequences.
我们报告了从人类5号染色体q13上脊髓性肌萎缩症（SMA）区域分离和鉴定新的表达序列的情况。基于序列同源性研究，这些cDNA被分为四类，其中一类与β-葡萄糖醛酸酶（BG）基因有广泛的同源性，但外显子排列不同。其他cDNA与已知DNA序列没有任何强烈的同源性。
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