Babovic-Vuksanovic D, Donaldson M D, Gibson N A, Wallace A M
Department of Child Health, Glasgow University, UK.
Acta Paediatr. 1994 Sep;83(9):994-7. doi: 10.1111/j.1651-2227.1994.tb13192.x.
An eight-year-old boy with Leydig cell hyperplasia (testotoxicosis) was admitted with a three-day history of rash, vomiting and diarrhoea, followed by acute onset of breathlessness and confusion. He was shocked, with liver cell and renal failure, erythematous rash and severe interstitial pneumonitis. He had been treated with ketoconazole for four years prior to admission, receiving 1200mg daily during the preceding year. Cessation of ketoconazole therapy was associated with full clinical recovery but relapse of testotoxicosis. Ketoconazole was reintroduced cautiously at a lower dose, with no ill-effect, and reasonable control of testotoxicosis. We conclude that this boy's illness, including the interstitial pneumonitis, represented a reaction to ketoconazole which was dose-related rather than idiosyncratic.
一名患有莱迪希细胞增生症（睾丸中毒症）的8岁男孩因出现皮疹、呕吐和腹泻3天，随后急性发作呼吸困难和意识模糊入院。他出现休克，伴有肝细胞和肾衰竭、红斑疹及严重的间质性肺炎。入院前他已接受酮康唑治疗4年，前一年每日服用1200毫克。停用酮康唑治疗后临床完全康复，但睾丸中毒症复发。以较低剂量谨慎重新使用酮康唑后，未出现不良影响，且睾丸中毒症得到合理控制。我们得出结论，该男孩的病症，包括间质性肺炎，是对酮康唑的一种剂量相关而非特异质性的反应。
