Tarlatzis B C, Grimbizis G, Pournaropoulos F, Bontis J, Lagos S, Pados G, Mantalenakis S
First Department of OB/GYN, Aristotelian University of Thessaloniki, Greece.
J Assist Reprod Genet. 1994 Feb;11(2):85-91. doi: 10.1007/BF02215993.
The administration of two GnRH analogues (buserelin and leuprolide acetate) in long and short protocols was evaluated prospectively. In the long protocol, the analogues were given from day 1 of the cycle for at least 14 days and then hMG administration was started, while in the short protocol the analogues were initiated from cycle day 1, adding hMG from day 3. The patients were divided into four groups according to the protocol used: Group I, buserelin-long; Group II, buserelin-short; Group III, leuprolide-long; and Group IV, leuprolide-short. Serum E2 levels on the day of hCG injection and the number of follicles observed, oocytes retrieved, and embryos obtained, as well as implantation rates, were significantly higher (P < 0.001) in the long protocols than in the short ones.
Pregnancy rates were similar in all groups, although a trend for better results was observed in buserelin-long compared to buserelin-short. There were no differences in the results achieved with buserelin or leuprolide.
The administration of GnRH analogues (buserelin and leuprolide acetate) in long protocols induced a more intense ovarian response and was associated with significantly higher implantation rates and also a trend for higher pregnancy rates, although this difference was not statistically significant.
前瞻性评估两种促性腺激素释放激素类似物（布舍瑞林和醋酸亮丙瑞林）在长方案和短方案中的应用情况。在长方案中，从周期第1天开始给予类似物至少14天，然后开始应用人绝经期促性腺激素（hMG），而在短方案中，从周期第1天开始给予类似物，从第3天开始加用hMG。根据所采用的方案将患者分为四组：第一组，布舍瑞林-长方案；第二组，布舍瑞林-短方案；第三组，醋酸亮丙瑞林-长方案；第四组，醋酸亮丙瑞林-短方案。与短方案相比，长方案中在注射hCG当天的血清雌二醇（E2）水平、观察到的卵泡数量、获取的卵母细胞数量、获得的胚胎数量以及着床率均显著更高（P < 0.001）。
所有组的妊娠率相似，尽管与布舍瑞林-短方案相比，布舍瑞林-长方案有取得更好结果的趋势。使用布舍瑞林或醋酸亮丙瑞林所取得的结果无差异。
在长方案中应用促性腺激素释放激素类似物（布舍瑞林和醋酸亮丙瑞林）可诱导更强的卵巢反应，且与显著更高的着床率以及更高妊娠率的趋势相关，尽管这种差异无统计学意义。
