奥沙米特和KW-4679对豚鼠鼻腺离体腺泡中乙酰胆碱诱导反应的影响。

Effects of oxatomide and KW-4679 on acetylcholine-induced responses in the isolated acini of guinea pig nasal glands.

作者信息

Ikeda K, Wu D, Takasaka T

机构信息

Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Int Arch Allergy Immunol. 1995 Feb;106(2):157-62. doi: 10.1159/000236837.

DOI:10.1159/000236837

PMID:7819744

Abstract

The antiallergic drugs oxatomide and KW-4679 were assessed to show inhibitory effects on ionic currents and intracellular Ca2+ concentration ([Ca2+]i) increase induced by acetylcholine (ACh) in isolated acini of the guinea pig nasal gland. Both K+ and Cl- currents evoked by ACh were inhibited by addition of oxatomide and KW-4679 at the concentration of 10(-5) M. KW-4679 (10(-5) M) inhibited the increase in [Ca2+]i induced by ACh, whereas no effect of oxatomide (10(-5) M) on Ca2+ responses was observed. These findings suggest that both drugs suppress electrolyte and fluid secretion in the nasal glands by different mechanisms.

摘要

对抗过敏药物奥沙米特和KW - 4679进行了评估，以观察它们对豚鼠鼻腺分离腺泡中乙酰胆碱（ACh）诱导的离子电流和细胞内钙离子浓度（[Ca2+]i）升高的抑制作用。添加浓度为10(-5) M的奥沙米特和KW - 4679可抑制ACh诱发的K+和Cl-电流。KW - 4679（10(-5) M）可抑制ACh诱导的[Ca2+]i升高，而未观察到奥沙米特（10(-5) M）对钙离子反应有影响。这些发现表明，两种药物通过不同机制抑制鼻腺中的电解质和液体分泌。