Rai K R
Division of Hematology/Oncology, Long Island Jewish Medical Center, New Hyde Park, New York 11042.
Leuk Lymphoma. 1994;14 Suppl 1:107-8.
In 90 splenectomized patients with active HCL, this multi-institutional intergroup study showed that as compared to alpha interferon (aIF), pentostatin resulted in a higher incidence of response, but the difference was not statistically significantly. Pentostatin-induced remissions occurred significantly faster and such responses lasted significantly longer when compared with aIF induced remissions. there were no unusual toxicities observed in this study. This study confirms previous observations that both these agents have important place in therapy of hairy cell leukemia.
在90例患有活动性毛细胞白血病（HCL）的脾切除患者中，这项多机构组间研究表明，与α干扰素（aIF）相比，喷司他丁导致缓解的发生率更高，但差异无统计学意义。与aIF诱导的缓解相比，喷司他丁诱导的缓解出现得明显更快，且这种缓解持续的时间明显更长。在本研究中未观察到异常毒性。这项研究证实了先前的观察结果，即这两种药物在毛细胞白血病的治疗中都占有重要地位。
