Konishi-Imamura L, Sato M, Dohi K, Kadota S, Namba T, Kobashi K
Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Biol Pharm Bull. 1994 Aug;17(8):1018-22. doi: 10.1248/bpb.17.1018.
A novel type of arylsulfate sulfotransferase (ASST) from a predominant human intestinal bacterium catalyzes the stoichiometric transfer of a sulfate group from phenolic sulfate esters to phenols. We clarified that polyphenols were better substrates of this enzyme than the corresponding glycosides. Additionally, a coumarin derivative, esculetin, was sulfated by ASST at the 6-position to give 6-monosulfate. Therefore, ASST is more useful for the preparation of sulfated polyphenols at their specific hydroxyl groups and would play an important role in the metabolism of phenolic compounds in vegetable food and traditional medicines.
一种来自人类肠道优势菌的新型芳基硫酸酯硫酸转移酶（ASST）催化硫酸基团从酚硫酸酯向酚的化学计量转移。我们阐明，多酚是该酶比相应糖苷更好的底物。此外，香豆素衍生物七叶亭在6位被ASST硫酸化生成6 - 单硫酸盐。因此，ASST对于在特定羟基处制备硫酸化多酚更有用，并且在蔬菜食品和传统药物中酚类化合物的代谢中发挥重要作用。
