神经肌肉阻滞的动力学分析。II. 由d -筒箭毒碱和α -银环蛇毒素引起的四个成串刺激衰减

Kinetic analysis of neuromuscular blockade. II. Train-of-four fade induced by d-tubocurarine and alpha-bungarotoxin.

作者信息

Tajima T, Kato Y, Hatanaka T, Aiba T, Katayama K, Koizumi T

机构信息

Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Biol Pharm Bull. 1994 Aug;17(8):1089-93. doi: 10.1248/bpb.17.1089.

DOI:10.1248/bpb.17.1089

PMID:7820114

Abstract

The degree of train-of-four (TOF) fade, i.e., the reduction of the fourth to the first twitch height in a train, induced by d-tubocurarine (d-TC) and alpha-bungarotoxin (alpha-BX) was investigated. The fade induced by d-TC was pronounced in comparison with that by alpha-BX, and the difference was analyzed using a kinetic model. Based on the assumptions: (1) Acetylcholine (ACh) binds to the nicotinic receptor and evokes twitch response. (2) The amount of released ACh is dependent on stimulus interval. (3) d-TC interacts competitively with the receptor. (4) alpha-BX interacts irreversibly with the receptor. It was suggested that the fade by d-TC and alpha-BX can be explained by the difference of the receptor occupancy by ACh which was caused by different interaction mechanisms of the two muscle relaxants with receptors.

摘要

研究了由右旋筒箭毒碱（d-TC）和α-银环蛇毒素（α-BX）引起的四个成串刺激（TOF）衰减程度，即一串刺激中第四个抽搐高度相对于第一个抽搐高度的降低。与α-BX相比，d-TC引起的衰减更为明显，并使用动力学模型分析了这种差异。基于以下假设：（1）乙酰胆碱（ACh）与烟碱受体结合并引发抽搐反应。（2）释放的ACh量取决于刺激间隔。（3）d-TC与受体竞争性相互作用。（4）α-BX与受体不可逆地相互作用。结果表明，d-TC和α-BX引起的衰减可以通过两种肌肉松弛剂与受体的不同相互作用机制导致的ACh受体占有率差异来解释。