Grasby P M, Frith C D, Friston K J, Simpson J, Fletcher P C, Frackowiak R S, Dolan R J
MRC Cyclotron Unit, Hammersmith Hospital, London, UK.
Brain. 1994 Dec;117 ( Pt 6):1271-82. doi: 10.1093/brain/117.6.1271.
Positron emission tomography measurements of regional cerebral blood flow (rCBF) were performed in normal volunteers during a graded auditory-verbal memory task. Subjects were required to remember and then immediately, and freely, recall a series of auditorily presented word lists varying from two to 13 words in length. Significant regional correlations between rCBF and memory load (word list length) were identified using statistical parametric mapping. Increasing memory load correlated with increasing rCBF in the cerebellar vermis and hemispheres, thalamus bilaterally, the superior and middle frontal gyri bilaterally, anterior insular regions bilaterally, anterior cingulate, precuneus and left and right lateral premotor areas. Increasing memory load also correlated with decreasing rCBF in the left and right superior temporal/insular regions, medial frontal gyrus, Brodmann's area 37 bilaterally, cuneus, inferior parietal lobule bilaterally and the mid-portion of the cingulate cortex. The pattern of rCBF change closely resembled that identified in a previously reported study using a cognitive subtraction paradigm and provides further evidence for a widespread neural system subserving auditory-verbal memory. The patterns of rCBF response suggest that the areas identified are associated with limited capacity processes for encoding and retrieval.
在一项分级听觉言语记忆任务中，对正常志愿者进行了正电子发射断层扫描测量局部脑血流量（rCBF）。受试者需要记住并随后立即自由回忆一系列听觉呈现的单词列表，单词列表长度从两个到13个不等。使用统计参数映射确定了rCBF与记忆负荷（单词列表长度）之间显著的区域相关性。记忆负荷增加与小脑蚓部和半球、双侧丘脑、双侧额上回和额中回、双侧前岛叶区域、前扣带回、楔前叶以及左右外侧运动前区的rCBF增加相关。记忆负荷增加还与左右颞上/岛叶区域、内侧额回、双侧布罗德曼37区、楔叶、双侧顶下小叶以及扣带回皮质中部的rCBF减少相关。rCBF变化模式与先前使用认知减法范式报道的研究中确定的模式非常相似，并为服务于听觉言语记忆的广泛神经系统提供了进一步证据。rCBF反应模式表明所确定的区域与编码和检索的有限容量过程相关。
