Liu Yuanyuan, Zhong Zongye, Chen Jian, Kuo Hochieh, Chen Xiuli, Wang Ping, Shi Mingfang, Yang Mingzhen, Liu Bangzhong, Liu Guanghua
Department of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Rehabilitation Medicine, Shanghai Geriatric Medical Center, Shanghai, China.
Front Neurol. 2024 Aug 12;15:1419128. doi: 10.3389/fneur.2024.1419128. eCollection 2024.
To explore the activation patterns in the frontal cortex of patients with post-stroke cognitive impairment during the execution of working memory tasks.
15 patients with post-stroke cognitive impairment, 17 patients without cognitive impairment, and 15 healthy controls of similar age and sex were included. All participants under-went immediate recall task testing and near-infrared spectroscopy imaging to measure frontal cortex activation during the task.
The healthy control group performed the best in the immediate recall task, followed by the post-stroke non-cognitive impairment group. The post-stroke cognitive impairment group had the poorest performance. The near-infrared spectroscopy results revealed that during the immediate recall task, the healthy control group primarily activated the left frontal lobe region. In contrast, post-stroke patients exhibited reduced activation in the left frontal lobe and increased activation in the right frontal cortex, particularly in the right frontopolar and orbitofrontal regions, with the post-stroke cognitive impairment group displaying the most pronounced changes.
Patients with post-stroke cognitive impairment exhibit reduced activation in the left prefrontal cortex during the working memory tasks. They rely on compensatory activation in the right prefrontal cortex, particularly in the frontopolar and orbitofrontal cortex, to successfully complete the task.
探讨中风后认知障碍患者在执行工作记忆任务时额叶皮质的激活模式。
纳入15例中风后认知障碍患者、17例无认知障碍的患者以及15名年龄和性别相仿的健康对照者。所有参与者均接受即时回忆任务测试及近红外光谱成像，以测量任务期间额叶皮质的激活情况。
健康对照组在即时回忆任务中表现最佳，其次是中风后无认知障碍组。中风后认知障碍组表现最差。近红外光谱结果显示，在即时回忆任务期间，健康对照组主要激活左额叶区域。相比之下，中风后患者左额叶激活减少，右额叶皮质激活增加，尤其是右额极和眶额区域，中风后认知障碍组的变化最为明显。
中风后认知障碍患者在工作记忆任务期间左前额叶皮质激活减少。他们依靠右前额叶皮质，尤其是额极和眶额皮质的代偿性激活来成功完成任务。
