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Polyethylene glycol as a solvent for diazepam: bioavailability and clinical effects after intramuscular administration, comparison of oral, intramuscular and rectal administration, and precipitation from intravenous solutions.

作者信息

Korttila K, Sothman A, Andersson P

出版信息

Acta Pharmacol Toxicol (Copenh). 1976 Jul;39(1):104-17. doi: 10.1111/j.1600-0773.1976.tb03161.x.

DOI:10.1111/j.1600-0773.1976.tb03161.x
PMID:782157
Abstract
摘要

相似文献

1
Polyethylene glycol as a solvent for diazepam: bioavailability and clinical effects after intramuscular administration, comparison of oral, intramuscular and rectal administration, and precipitation from intravenous solutions.
Acta Pharmacol Toxicol (Copenh). 1976 Jul;39(1):104-17. doi: 10.1111/j.1600-0773.1976.tb03161.x.
2
Absorption of diazepam in man following rectal and parenteral administration.地西泮经直肠和非肠道给药后在人体中的吸收情况。
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Effect of organic cosolvent-induced skeletal muscle damage on the bioavailability of intramuscular [14C]diazepam.有机助溶剂诱导的骨骼肌损伤对肌肉注射[14C]地西泮生物利用度的影响。
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Bioavailability of diazepam after intravenous, oral and rectal administration in adult epileptic patients.地西泮在成年癫痫患者中静脉注射、口服及直肠给药后的生物利用度。
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Diazepam metabolism in normal man. I. Serum concentrations and clinical effects after intravenous, intramuscular, and oral administration.正常人地西泮的代谢。I. 静脉注射、肌肉注射及口服给药后的血清浓度及临床效应
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6
[Comparison of the bioavailability of two diazepam preparations. Clinical comparison between a new commercial preparation and a standard preparation after oral and intramuscular administration].
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Plasma concentrations of diazepam and N-desmethyldiazepam in newborn infants after intravenous, intramuscular, rectal and oral administration.
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Plasma concentration of diazepam and N-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam.儿童单次直肠或肌肉注射地西泮后血浆中地西泮和N-去甲基地西泮的浓度。
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Intramuscular bioavailability of chlorazepate as compared to diazepam.与地西泮相比，氯氮䓬的肌内生物利用度。
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Pharmacokinetics of diazepam after intravenous, intramuscular and oral administration to humans.
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引用本文的文献

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Supersaturated state of diazepam injection following dilution with infusion fluid.地西泮注射液用输液稀释后的过饱和状态。
J Pharm Health Care Sci. 2015 Mar 9;1:9. doi: 10.1186/s40780-014-0009-9. eCollection 2015.
2
The impact of dosing interval in a novel tandem oral dosing strategy: enhancing the exposure of low solubility drug candidates in a preclinical setting.新型串联口服给药策略中给药间隔的影响：在临床前环境中提高低溶解度候选药物的暴露量。
J Drug Deliv. 2011;2011:528284. doi: 10.1155/2011/528284. Epub 2011 Jan 12.
3
Rectal drug administration: clinical pharmacokinetic considerations.
直肠给药：临床药代动力学考量
Clin Pharmacokinet. 1982 Jul-Aug;7(4):285-311. doi: 10.2165/00003088-198207040-00002.
4
Flunitrazepam: a review of its pharmacological properties and therapeutic use.氟硝西泮：其药理特性与治疗用途综述
Drugs. 1980 Nov;20(5):353-74. doi: 10.2165/00003495-198020050-00002.
5
Use of an in vitro model for the assessment of muscle damage from intramuscular injections: in vitro-in vivo correlation and predictability with mixed solvent systems.使用体外模型评估肌肉注射引起的肌肉损伤：体外-体内相关性及混合溶剂系统的可预测性
Pharm Res. 1989 Sep;6(9):766-71. doi: 10.1023/a:1015971429942.
6
An in vitro model to evaluate muscle damage following intramuscular injections.一种用于评估肌肉注射后肌肉损伤的体外模型。
Pharm Res. 1989 Feb;6(2):167-70. doi: 10.1023/a:1015940811827.
7
[Impairment of performance by alcohol and diazepam (author's transl)].
Z Rechtsmed. 1979 Mar 8;82(4):327-36. doi: 10.1007/BF02092045.
8
Pharmacokinetics of intravenous anaesthetics: implications for clinical use.静脉麻醉药的药代动力学：对临床应用的影响。
Clin Pharmacokinet. 1977 Sep-Oct;2(5):344-72. doi: 10.2165/00003088-197702050-00003.