Deragon K L, Sower S A
Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham 03824.
Gen Comp Endocrinol. 1994 Sep;95(3):363-7. doi: 10.1006/gcen.1994.1134.
The biological activities of lamprey gonadotropin-releasing hormone-III (GnRH-III) were determined in the adult male sea lamprey, Petromyzon marinus. One injection of lamprey GnRH-III at 0.1 or 0.2 microgram/g body wt stimulated plasma estradiol and progesterone levels in adult male sea lampreys undergoing final maturation. Four successive injections of lamprey GnRH-III at 0.1 microgram/g of lamprey GnRH-1 at 0.2 microgram/g induced spermiation in 78 or 30% of the lampreys, respectively, compared to 0% in controls by Day 16. In summary, lamprey GnRH-III is biologically active in stimulating the pituitary-gonadal axis in adult male lampreys.
在成年雄性海七鳃鳗（Petromyzon marinus）中测定了七鳃鳗促性腺激素释放激素III（GnRH-III）的生物活性。以0.1或0.2微克/克体重单次注射七鳃鳗GnRH-III，可刺激处于最终成熟阶段的成年雄性海七鳃鳗的血浆雌二醇和孕酮水平。连续四次以0.1微克/克的剂量注射七鳃鳗GnRH-III或以0.2微克/克的剂量注射七鳃鳗GnRH-1，到第16天时，分别有78%或30%的七鳃鳗排精，而对照组为0%。总之，七鳃鳗GnRH-III在刺激成年雄性七鳃鳗的垂体-性腺轴方面具有生物活性。
