Smart D, Johnston C F, Curry W J, Williamson R, Maule A G, Skuce P J, Shaw C, Halton D W, Buchanan K D
Comparative Neuroendocrinology Research Group, School of Clinical Medicine, Queen's University of Belfast, Northern Ireland.
J Comp Neurol. 1994 Sep 15;347(3):426-32. doi: 10.1002/cne.903470308.
The allatostatins are a family of peptides isolated originally from the cockroach, Diploptera punctata. Related peptides have been identified in Periplaneta americana and the blowfly, Calliphora vomitoria. These peptides have been shown to be potent inhibitors of juvenile hormone synthesis in these species. A peptide inhibitor of juvenile hormone biosynthesis has also been isolated from the moth, Manduca sexta; however, this peptide has no structural homology with the D. punctata-type allatostatins. Investigations of the phylogeny of the D. punctata allatostatin peptide family have been started by examining a number of nonarthropod invertebrates for the presence of allatostatin-like molecules using immunocytochemistry with antisera directed against the conserved C-terminal region of this family. Allatostatin-like immunoreactivity (ALIR) was demonstrated in the nervous systems of Hydra oligactis (Hydrozoa), Moniezia expansa (Cestoda), Schistosoma mansoni (Trematoda), Artioposthia triangulata (Turbellaria), Ascaris suum (Nematoda), Lumbricus terrestris (Oligochaeta), Limax pseudoflavus (Gastropoda), and Eledone cirrhosa (Cephalopoda). ALIR could not be demonstrated in Ciona intestinalis (Ascidiacea). These results suggest that molecules related to the allatostatins may play an important role in nervous system function in many invertebrates as well as in insects and that they also have an ancient evolutionary lineage.
咽侧体抑制素是最初从蜚蠊 Diploptera punctata 中分离出来的一类肽。在美洲大蠊和丽蝇 Calliphora vomitoria 中也鉴定出了相关肽。这些肽已被证明是这些物种中保幼激素合成的有效抑制剂。一种保幼激素生物合成的肽抑制剂也已从烟草天蛾 Manduca sexta 中分离出来；然而，这种肽与 Diploptera punctata 型咽侧体抑制素没有结构同源性。通过使用针对该家族保守 C 末端区域的抗血清进行免疫细胞化学，检查一些非节肢动物无脊椎动物中是否存在咽侧体抑制素样分子，从而开始了对 Diploptera punctata 咽侧体抑制素肽家族系统发育的研究。在寡聚水螅（水螅纲）、扩展莫尼茨绦虫（绦虫纲）、曼氏血吸虫（吸虫纲）、三角涡虫（涡虫纲）、猪蛔虫（线虫纲）、蚯蚓（寡毛纲）、伪黄蛞蝓（腹足纲）和卷腕乌贼（头足纲）的神经系统中发现了咽侧体抑制素样免疫反应性（ALIR）。在玻璃海鞘（海鞘纲）中未发现 ALIR。这些结果表明，与咽侧体抑制素相关的分子可能在许多无脊椎动物以及昆虫的神经系统功能中发挥重要作用，并且它们也有古老的进化谱系。
