Das P K, Chhotaray M K, Rath R N, Kar S, Das B, Parida B
Department of Medicine, SCB Medical College, Cuttack.
J Indian Med Assoc. 1994 Oct;92(10):328-30.
Fifty-six febrile episodes in 30 haematological malignancy cases were evaluated. Of these episodes 60.7% were in leukaemia cases. Clinical evaluation and investigation suggested infection in 42 episodes (75%) of fever and in rest 14 (25%) no identifiable cause could be found. Bacterial infection predominated with an incidence of 80.9% followed by fungal infection in 11.9% and parasitic infection in 7.1% of the febrile episodes. Gram-negative bacteria were more frequently isolated (22/34) than Gram-positive bacteria (12/34). Staph aureus was the commonest Gram-positive organism. Kl pneumoniae and Esch coli were the common Gram-negative pathogens. The commonest organisms were sensitive to cephalosporin and gentamicin. Incidence of fever due to infection was significantly higher (p < 0.001) in patients with absolute neutropenia, in whom the mortality rate was significantly higher (p < 0.001).
对30例血液系统恶性肿瘤患者的56次发热发作进行了评估。其中，60.7%的发作发生在白血病患者中。临床评估和检查表明，42次（75%）发热发作存在感染，其余14次（25%）未发现明确病因。细菌感染占主导，发热发作的发生率为80.9%，其次是真菌感染，占11.9%，寄生虫感染占7.1%。革兰氏阴性菌（22/34）比革兰氏阳性菌（12/34）更常被分离出来。金黄色葡萄球菌是最常见的革兰氏阳性菌。肺炎克雷伯菌和大肠杆菌是常见的革兰氏阴性病原体。最常见的病原体对头孢菌素和庆大霉素敏感。绝对中性粒细胞减少患者因感染导致的发热发生率显著更高（p<0.001），其死亡率也显著更高（p<0.001）。
