Tatekawa T, Yokota T, Oji Y, Moriyama Y, Tominaga N, Teshima H, Hiraoka A, Nakamura H, Shibata H, Minamishima Y
Fifth Department of Internal Medicine, Center for Adult Diseases, Osaka.
Rinsho Ketsueki. 1994 Nov;35(11):1261-6.
Eighteen patients underwent allogeneic bone marrow transplantation (allo. BMT) during the period May, 1991 to December, 1992 in the Center for Adult Diseases, Osaka. They were monitored for cytomegalovirus (CMV) antigenemia and arterial oxygen saturation (SaO2). More than 10 antigen-positive cells per 50,000 polymorphonuclear leukocytes were detected in five of 18 patients. Three of these 5 patients developed CMV pneumonia several weeks after the first detection of more than 10 positive cells. Six of 18 patients developed interstitial pneumonia (IP) (3 CMV pneumonia and 3 idiopathic IP). SaO2 decreased less than 95% several days before the development of IP in 3 of these 6 patients (2 of CMV pneumonia and 1 of idiopathic IP). CMV antigenemia assay and SaO2 assay were thus both considered to be useful for the early detection or prediction of development of CMV pneumonia.
1991年5月至1992年12月期间，18名患者在大阪成人疾病中心接受了异基因骨髓移植（allo.BMT）。对他们进行了巨细胞病毒（CMV）抗原血症和动脉血氧饱和度（SaO2）监测。18名患者中有5名每50,000个多形核白细胞中检测到超过10个抗原阳性细胞。这5名患者中有3名在首次检测到超过10个阳性细胞几周后发生了CMV肺炎。18名患者中有6名发生了间质性肺炎（IP）（3例CMV肺炎和3例特发性IP）。这6名患者中有3名（2例CMV肺炎和1例特发性IP）在IP发生前几天SaO2降至95%以下。因此，CMV抗原血症检测和SaO2检测都被认为对CMV肺炎的早期检测或发展预测有用。
