Bouza H, Rutherford M, Acolet D, Pennock J M, Dubowitz L M
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Neuropediatrics. 1994 Aug;25(4):201-7. doi: 10.1055/s-2008-1073022.
Neonates with unilateral hemispheric lesions detected by imaging in the newborn period are at risk for developing hemiplegia. Five full-term infants with predominantly unilateral lesions identified by cranial ultrasound in the neonatal period and confirmed with MRI were examined clinically at regular intervals in order to establish the development, incidence and evolution of later hemiplegia and the evolution of hemiplegic signs. In the neonatal period the infants had either a normal examination or subtle transient abnormalities. Abnormalities were not seen until 6 months of age in infants who developed hemiplegia. The number of hemiplegic signs in each child increased with time, the earlier the signs appeared the more severe the hemiplegia. In some infants deterioration with loss of preexisting skills was observed. At 24 months two of the infants were normal, one had a mild and two a moderate hemiplegia.
新生儿期经影像学检查发现有单侧半球病变的新生儿有发生偏瘫的风险。对5例在新生儿期经头颅超声检查发现主要为单侧病变并经MRI证实的足月儿进行定期临床检查，以确定后期偏瘫的发生、发生率和演变情况以及偏瘫体征的演变。在新生儿期，这些婴儿要么检查正常，要么有轻微的短暂异常。发生偏瘫的婴儿直到6个月大时才出现异常。每个孩子的偏瘫体征数量随时间增加，体征出现得越早，偏瘫越严重。在一些婴儿中观察到原有技能丧失导致的病情恶化。在24个月时，其中2例婴儿正常，1例有轻度偏瘫，2例有中度偏瘫。
