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[应激状态下成年和老年大鼠心肌脂质过氧化活性的变化]

[Changes in the activity of lipid peroxidation in the myocardium of adult and aged rats under stress].

作者信息

Markova E A, Misula I R

出版信息

Patol Fiziol Eksp Ter. 1994 Jul-Sep(3):37-8.

PMID:7824344
Abstract

The levels of lipid peroxidation (LPO) products, the antioxidative system and morphometric changes were studied in the myocardium of adult (8-10-month) and old (20-24-month) male rats in different periods after their exposure to stress. The findings suggest that the maximum damaging action occurs 18-60 hours of poststress. The high activity of LPO and the low activity of the antioxidative system in the hearts of the old animals determine more substantial impact of stress on the myocardium of this group of animals.

摘要

研究了成年(8 - 10个月)和老年(20 - 24个月)雄性大鼠在应激后不同时间段心肌中脂质过氧化(LPO)产物水平、抗氧化系统及形态学变化。研究结果表明,应激后18 - 60小时出现最大损伤作用。老年动物心脏中LPO的高活性和抗氧化系统的低活性决定了应激对该组动物心肌的影响更大。

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