衰老诱导的雄性和雌性大鼠多巴胺能系统的行为及神经化学变化。

Behavioral and neurochemical changes induced by aging in dopaminergic systems of male and female rats.

作者信息

Dorce V A, Palermo-Neto J

机构信息

Pharmacology Lab., Butantan Institute, São Paulo, SP, Brasil.

出版信息

Physiol Behav. 1994 Nov;56(5):1015-9. doi: 10.1016/0031-9384(94)90337-9.

DOI:10.1016/0031-9384(94)90337-9

PMID:7824565

Abstract

Changes induced by aging in dopaminergic activity of male and female rats were compared by behavioral and neurochemical methods. Young (3 months) and old (23 months) rats were used. Aging decreased animal activity in the open field and increased apomorphine-induced stereotyped behavior. No differences in open field data were observed between males and females. Young and aged female rats had higher striatal DA and HVA levels than males; aging induced a decrease in both striatal DA and HVA levels in males, but not in females. No changes in HVA/DA ratios were observed among the different groups. These results show that aging reduces nigrostriatal activity as well as nigrostriatal DA levels. Furthermore, they indicate that time course events related to aging differ between males and females.

摘要

通过行为学和神经化学方法比较了衰老对雄性和雌性大鼠多巴胺能活性的影响。使用了年轻（3个月）和年老（23个月）的大鼠。衰老降低了动物在旷场中的活动，并增加了阿扑吗啡诱导的刻板行为。在旷场数据方面，未观察到雄性和雌性之间存在差异。年轻和年老的雌性大鼠纹状体多巴胺（DA）和高香草酸（HVA）水平高于雄性；衰老导致雄性大鼠纹状体DA和HVA水平均下降，但雌性大鼠未出现这种情况。不同组之间未观察到HVA/DA比值的变化。这些结果表明，衰老会降低黑质纹状体活性以及黑质纹状体DA水平。此外，它们还表明，与衰老相关的时间进程事件在雄性和雌性之间存在差异。