Ginzler E, Diamond H, Guttadauria M, Kaplan D
Arthritis Rheum. 1976 Jul-Aug;19(4):693-9. doi: 10.1002/1529-0131(197607/08)19:4<693::aid-art1780190406>3.0.co;2-2.
A 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.
对14例弥漫性狼疮性肾炎患者进行了一项为期1年的双盲交叉研究，比较泼尼松和硫唑嘌呤与泼尼松加小剂量硫唑嘌呤及环磷酰胺的疗效。小剂量三联疗法与泼尼松加硫唑嘌呤相比并无明显治疗优势。小剂量使用环磷酰胺并不能避免其所致的卵巢功能衰竭和血尿。
